Wednesday, October 21, 2026

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CDC Confirms Third U.S. Measles Death of 2026 as Cases Climb Past 4,400

The nation’s worst measles outbreak in decades has reached 47 jurisdictions, with Pennsylvania the hardest hit.

By 2 min read
Measles virus particle under electron microscope
Date: ??Courtesy of C. S. Goldsmith; William Bellini, Ph.D.This thin-section transmission electron micrograph (TEM) revealed the ultrastructural appearance of a single virus particle, or ?virion?, of measles virus. The measles virus is a <i>paramyxovirus</i>, genus <i>Morbillivirus</i>. It is 100-200 nm in diameter, with a core of single-stranded RNA, and is closely related to the <i>rinderpest</i> and <i>canine distemper</i> viruses. Two membrane envelope proteins are important in pathogenesis. They are the F (fusion) protein, which is responsible for fusion of virus and host cell membranes, viral penetration, and hemolysis, and the H (hemagglutinin) protein, which is responsible for adsorption of virus to cells.<p>There is only one antigenic type of measles virus. Although studies have documented changes in the H glycoprotein, these changes do not appear to be epidemiologically important (i.e., no change in vaccine efficacy has been observed).Prior to 1963, almost everyone got measles; it was an expected life event. Each year in the U.S. there were approximately 3 to 4 million cases and an average of 450 deaths, with epidemic cycles every 2 to 3 years. More than half the population had measles by the time they were 6 years old, and 90 % had the disease by the time they were 15. This indicates that many more cases were occurring than were being reported. However, after the vaccine became available, the number of measles cases dropped by 98 % and the epidemic cycles drastically diminished.<p>Measles virus is rapidly inactivated by heat, light, acidic pH, ether, and trypsin. It has a short survival time (<2 hours) in the air, or on objects and surfaces.

ATLANTA, Oct. 20 (TodayViralUSA) — The Centers for Disease Control and Prevention on Tuesday confirmed a third measles-related death in the United States this year, as the country contends with its largest measles outbreak in decades.

The agency did not say in which state the death occurred, Al Jazeera reported. The CDC added the death to its federal tally after the National Center for Health Statistics verified that measles was listed as the underlying cause on a death certificate.

Cases nearly double last year’s total

As of Oct. 15, the CDC counted 4,410 confirmed measles cases in 2026, including 18 among international visitors. Cases have been reported in 47 jurisdictions, and 96% are linked to outbreaks, according to the agency’s tracker. The CDC has recorded 42 new outbreaks this year.

That total is nearly double the 2,289 cases reported in all of 2025, according to the National Public Health Information Coalition, citing CDC data.

Pennsylvania has been hit hardest. The state had reported 1,286 cases and five deaths as of Monday, with the outbreak spreading from its starting point in Lancaster County to 42 counties, Al Jazeera reported.

A count under scrutiny

The federal death toll is lower than the figures reported by some state health officials, because the CDC now relies on NCHS mortality data rather than state reports. The agency says its count could change as reviews are completed, and that it is working with the Council of State and Territorial Epidemiologists on a standard definition for measles deaths.

Health officials have pointed to falling childhood vaccination rates. Only 92.4% of kindergarteners received the measles, mumps and rubella vaccine in the 2025-26 school year, below the 95% coverage considered necessary to prevent widespread outbreaks, according to the coalition.

Sources & Credits

Image: Transmission electron micrograph of a measles virus particle (file image), by Cynthia S. Goldsmith, CDC, Public domain, via Wikimedia Commons.

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